Multifunctional organic neural probes

In parallel with these developments, our research efforts will also focus on developing multifunctional organic neural probes. These are organic optoelectronic devices for optogenetics and other neuroscience applications such as calcium imaging or functional magnetic resonance imaging (fMRI). The focus will be on ultra-sensitive organic photodetectors (OPDs) and high-performance organic light-emitting diodes (OLEDs) that could replace conventional neural probes based on inorganic semiconductors, metal alloys and optical fibers. From a manufacturing perspective, key aspects include the design of multifunctional arrays, miniaturization, and encapsulation. Proof-of-concept organic neural probes will be evaluated using both in vitro and in vivo models through active international collaborations. In addition, our research will focus on developing a photo-stimulating device capable of spatially specific manipulation of biological processes. With respect to neuroscience applications, organic biosensing devices are targeted in the form of a smart wearable device capable of monitoring overall muscle function in patients with neurological movement disorders experiencing symptoms like muscle stiffness (or rigidity) and slowness of movement. This research will benefit patients with Parkinson’s Disease as well as those undertaking rehabilitation after a stroke.